International Circulation: Could you please explain how left ventricular end diastolic pressure (LVEDP) guided hydration in terms of the measurement itself?
Dr. Somjot Brar: The LVEDP is actually a fairly straight-forward measurement as it is made during every routine cardiac catheterization. The way we this was performed in the trial is how most perform it in clinical practice by placing a pig-tail catheter into the left ventricle and making a measurement in the standard fashion. That measurement is used to guide the rate of hydration as the patient is assigned based of their LVEDP. It effectively identifies patients who are going to be good candidates for a greater volume of hydration. At the same time， it identifies those who will likely benefit from hydration but to a moderated extent.
《国际循环》：能否请您解释一下根据左室舒张末期压力（LVEDP）指导的水化治疗？
Dr. Somjot Brar：LVEDP是一项非常直接的检测指标，每一常规心导管检查中均可检测。本试验中我们采用了临床实践中最常用的方式，即在左心室中置入猪尾导管，按照标准方法测量压力。这种测量值被用来指导根据LVEDP分组的患者水化治疗的级别。这些指标可有效识别出对更高容量水化产生良好疗效的患者。同时，还可识别出对中度水化治疗获益的患者。
　International Circulation: So this is just a onetime assessment? Or are you assessing throughout the procedure?
　Dr. Brar: It is a onetime assessment. It is made as the first measurement when the patient first enters the cathlab， prior to any contrast administration. Once the assessment is made， the fluid rates are set and then those fluid rates are continued for the duration of the procedure and for four hours post-procedure. There is not a need for a reassessment of the LVEDP value.
　《国际循环》：这是一次性的检测？您是否在整个操作过程中动态评估这项指标？
　Dr. Somjot Brar：是的，这是一次性的检查。这是患者首次行心导管检查时，注射对比剂之前进行的第一项检测指标。一旦测定完毕，即可设定液体量并应用于整个手术中以及术后4小时，不需重复测定LVEDP值。